Metronomics Global Health Initiative

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MGHI papers

category count 34 billets

Pilot study of a pediatric metronomic 4-drug regimen

We have just published the results of a paediatric metronomic pilot study taht lead to the METRO-SFCE01 phase II study. This regimen is safe. Further information regarding its efficacy will be available after completion of the phase II trial.

A mathematical model for the administration of temozolomide: comparative analysis of conventional and metronomic chemotherapy regimens.

Faivre C, Barbolosi D, Pasquier E, André N from INSERM UMR 911, Centre de Recherche en Oncologie Biologique et Oncopharmacologie and from the Metronomics Global Health Initiative have just published in Cancer Chemotherapy Pharmacology a new article entitled : A mathematical model for the administration of temozolomide: comparative analysis of (...)

Accidental Poisoning With 6-MP in a Sibling of Pediatric Patient Treated With Metronomic Maintenance Chemotherapy.

A recent article entitled "Accidental Poisoning With 6-MP in a Sibling of Pediatric Patient Treated With Maintenance Chemotherapy" has been published in the Journal of Pediatric Hematology and Oncology. The article has been written by clinicians (Fernandez, Arnaud MD; Gervoise-Boyer, Marie J. MD; Chambost, Hervé MD, PhD; Coze, Carole MD, PhD; Andre, (...)

Can metronomic maintenance with weekly vinblastine prevent early relapse/progression after bevacizumab–irinotecan in children with low-grade glioma?

Marie Amélie Heng, Laetitia Padovani, Philippe Dory-Lautrec, Jean Claude Gentet, Arnaud Verschuur, Eddy Pasquier, Dominique Figarella-Branger, Didier Scavarda and Nicolas André from the Service d’hématologie et Oncologie Pédiatrique, AP-HM, the Metronomics Global Health Initiative, and the Aix-Marseille Université, INSERM, CRO2 UMR_S 911, Marseille France (...)

Can Targeted Therapy be Successful without Metronomic Scheduling ?

Barton Kamen, Eddy Pasquier and Nicolas André have written for a special issue on target therapies for Currents Topics in Medicinal Chemistry a article entitled : Can Targeted Therapy be Successful without Metronomic Scheduling ? in which they discuss the importance of doses and schedule to increase specificity of anticancer treatments. ABSTRACT In (...)

Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells

Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells by Eddy Pasquier, Maria-Pia Tuset, Janine Street, Snega Sinnappan, Karen L. MacKenzie, Diane Braguer, Nicolas André, Maria Kavallaris from the Children’s Cancer Institute Australia for Medical Research, the (...)

Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-Based Metronomic Chemotherapy: A Bench to Bedside Study

Eddy Pasquier, Nicolas André, Janine Street, Anuradha Chougulee, Bharat Rekhif, Jaya Ghoshe, Deepa S.J. Philipe, Marie Meurer, Karen L. MacKenzie, Maria Kavallaris Shripad D. Banavali from the INSERM UMR 911, Centre de Recherche en Oncologie biologique et Oncopharmacologie, Aix-Marseille University, Metronomics, Global Health Initiative, the Service (...)

Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytoma

We have just published a preclinical study entitled : Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytoma that reports on the use of two repositionned drugs to treat low grade glioma. The authors of this study (Sandy Mercurio, Laetitia Padovani, Carole Colin, Manon Carré, Aurélie (...)

Has the time come for metronomics in low-income and middle-income countries?

In the May issue of the Lancet Oncology, We have published a "personnal view" paper about the potential use of Metronomics in low and middle income countries. We hope this publications will help us raise awareness about the potential of the approach and find new partners, supporters and ambassadors. ABSTRACT In 2008, 72% of cancer deaths occurred in (...)

Herbal Medicine Offers Great Potential in Support of Metronomic Cancer Therapy

Clara Bik-San Lau, Chun-Kwok Wong and Ping-Chung Leung from Partner State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, , Institute of Chinese Medicine, The Chinese University of Hong Kong and Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Konghve just published in (...)